Journal article
Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: A pilot study*
A Geloen, K Chapelier, A Cividjian, E Dantony, M Rabilloud, CN May, L Quintin
Critical Care Medicine | Published : 2013
Abstract
OBJECTIVE:: During septic shock, vasopressors are a cornerstone of therapy. In septic shock, very high doses of vasopressors sometimes have to be used due to vascular desensitization, the mechanisms of which are poorly understood. This study assesses whether α-2 agonists increase pressor responsiveness following lipopolysaccharide administration. DESIGN:: Parallel groups of animals (n = 7 per group) subjected to pharmacologic interventions. SETTING:: Physiology laboratory. SUBJECTS:: Rats. INTERVENTIONS:: In anesthetized rats, the pressor responses to increasing doses of norepinephrine (norepinephrine- systolic pressure curve) were assessed during a baseline period, after injection of saline..
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Grants
Awarded by University of Lyon
Awarded by NHMRC
Funding Acknowledgements
Supported, in part, by grant CarMeN from INSERM University of Lyon and EA 4316: Neurocardiology from University of Lyon.Dr. Quintin was supported by PEPS-CNRS 2010 and also received grants and honoraria from Bohringer-Ingelheim France, UCB Pharma, and Abbott International (1986-1995). Dr. Quintin holds a patent on the use of alpha-2 agonists in the setting of septic shock (FR 1053355). Dr. Rabilloud is employed by Hospices Civils de Lyon, Universite Lyon 1. Dr. May received grant support from the National Health and Medical Research Council of Australia and received financial support for travel and accommodation to speak at various scientific meetings. Dr. May was supported by NHMRC Research Fellowship (566819). The remaining authors have disclosed that they do not have any potential conflicts of interest.